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First, targeting of mature OLs without off-targets on the immature stages of the OL lineage may be important, given their differential susceptibilities to injury and responses to extrinsic factors

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2 Materials and methods 2.1 Drugs and reagents The reagents employed throughout this study included leonurine (20220301, Xinxiang Olan Biotechnology Co., Ltd), subsequently complemented by Ferrostatin-1 (Fer-1