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N Engl J Med 2016;375:31122.PubMedPMC References Fig

Monitor for any new or changing skin lesions and consult a healthcare provider if noted

The selectivity of the peptide is further discussed by the researchers, who suggest that senescent cells may depend more strongly on FOXO4-mediated control of p53 localization and activity, so disrupting that node might preferentially remove cells that are already operating close to an apoptotic threshold