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In a drug safety update, published on 28 January 2025, the MHRA cited findings of a recent European Medicines Agency (EMA) review of the available evidence for all GLP-1 and dual GIP/GLP-1 RAs, which concluded that data supports an association between the medicines and the potential risk of pulmonary aspiration during anaesthesia or deep sedation, owing to the delayed gastric emptying linked to these medicines

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To better differentiate the mechanisms of GLP-1RAs, we propose recruiting more individuals who are of normal weight and do not have diabetes or obesity for future clinical trials

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doi: 10.1074/jbc.M408893200 225 GongYWangNLiuN