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Both are intrinsically associated with the decrease in the quality and competence of gamete cell division, and, consequently, cause impairment of fertility (KE5 and Adverse Outcome)

A final precursor to consider in relation to the NRK pathway is the deamidated form of NRnicotinic acid riboside (NAR)

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This might occur through changes in the levels of enzymes or coenzymes participating in NAD + metabolism

Metabolite profiling of reduced thiol-containing metabolites was carried out in the presence of NEM

In Arabidopsis, there are nine annotated OPT genes (Koh et al., 2002)