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If persistent diarrhea or ongoing vomiting is making it impossible to maintain adequate hydration despite your best efforts, discuss dose adjustment with your prescribing physician

10.1245/s10434-012-2573-2 6

Except for excessive proliferation and apoptosis resistance of PASMCs, extracellular matrix remodeling is additional contributor to PVR [34]

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Comment: Some commenters agreed that the term upstream drivers encompasses a wider range of root causes of the problems that practitioners are addressing through CHI services, such as potential dietary, behavioral, medical, and environmental drivers to lessen the impacts of the problem(s) addressed in the initiating visit