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Uzuneser TC, Speidel J, Kogias G, Wang AL, de Souza Silva MA, Huston JP, et al

10 , eadl4909 (2025)

Altered expression of glutamate transporters, including the cystineglutamate transporter (xCT) system, increases concentrations of extracellular glutamate, which contribute to epileptic discharge, tumour proliferation and peripheral excitotoxicity

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The primary outcomes were the one-year cumulative incidence of acute coronary syndromes, coronary artery disease encounters, heart failure, stroke, and all-cause mortality, assessed both during treatment and after discontinuation