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doi: 10.1073/pnas.1104383108 54 KokkinopoulouIMoutsatsouP

Approximately 2030% of patients on GLP-1 receptor agonists report suboptimal weight loss or tolerability challenges, often leading them to believe the medication simply doesn't work for their body

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Researchers demonstrated through optogenetic stimulation studies that activation of the GLP-1 receptor in this MHb-IPN circuit eliminates nicotine reward and reduces nicotine intake

While some individuals report temporary symptom relief, others may experience worsening mood, increased anxiety, or emotional blunting