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During an implicit memory task, in which PD patients are often severely impaired, the researchers noted lower concentrations of GABA and glutamate than they would expect from normal patients (Buchanan et al., 2014)

Measuring body composition (fat versus lean mass) should become routine in the management of patients on GLP-1 medications. The Takeaway While GLP-1 medications are effective for weight loss, rapid weight reduction can lead to significant loss of fat-free mass, including muscle

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Limited options NICE points out that, until now, people with obesity have had limited treatment options and there is a large unmet need in this population

This genetic context does not replace clinical evaluation but can help inform discussions with your prescribing provider about the best treatment fit for your biology

The objective is not indefinite medication use, nor abrupt discontinuation without a plan