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B12 deficiency leads to megaloblastic anaemia, producing fewer and abnormally large red blood cells with reduced oxygen-carrying capacity

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About 70% of patients on Wegovy tolerate the full 2.4 mg maintenance dose

Genetically modified folate overproducing strains of some fungi and bacteria have been constructed, e.g., Ashbya gossypii , Escherichia coli , and Bacillus subtilis , the first being the best folate producer reported to date with folate titers of 6.6 mg/L (i.e., 146-fold higher than the wild strain) 631,632,633,634