Putting it together: Why patients and practitioners dont see the adverse effects of GLP-1 agonists on sexual desire In exploring the influence that GLP-1 agonists have on sexual desire through a biopsychosocial framework, it becomes clear that there are likely several competing contributing factors, and our short list is far from exhaustive
The full data are due at a medical meeting and in a peer-reviewed journal later in 2026
Other reasons for infertility include congenital factors, and health conditions like prostatitis and diabetes that can affect sperm production
Temporary skin darkening (hyperpigmentation) can occur, especially in those with darker skin tones and those with tanned skin, but this side effect is uncommon if specialized lasers for darker skin are utilized
Monitoring for new autoimmune manifestations Although rare, the possibility that GLP-1/GIP receptor agonism could trigger new autoimmune manifestations in susceptible individuals has been raised by case reports
Novel GLP-1 mimetics in diabetes: lixisenatide and albiglutide