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No study examined tolerance or dependence with extended use, and no study followed a repeated-dosing cohort beyond a few months

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Percentage improvements continued past 3 years in those who remained on treatment

Besides, other transporters such as SLC38A1/SNAT1 and SLC38A2/SNAT2 can compensate for the depletion of SLC1A5/ASCT2 to contribute to glutamine uptake [66]