The defining differentiator is glucagon receptor (GCGR) activation which uniquely boosts thermogenesis and energy expenditure, actively fighting the metabolic slowdown that accompanies caloric restriction
Additionally, exercise improved lipid metabolism by mitigating obesity, which contributed to decreased inflammatory responses and, consequently, lowered systemic TNF levels (Huang et al., 2022)
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Novel GLP-1 agonist dulaglutide wins AWARD for type 2 diabetes AT THE ADA ANNUAL SCIENTIFIC SESSIONS CHICAGO Dulaglutide, an investigational once-weekly long-acting glucagonlike peptide1 receptor agonist, provided superior glycemic control compared with sitagliptin in patients with type 2 diabetes in the phase III AWARD-5 trial