[DOI] [PMC free article] [PubMed] [Google Scholar] 251.Prokopieva V.D., Yarygina E.G., Bokhan N.A., Ivanova S.A
Bacteriostatic water is directed down the inner wall of the vial rather than sprayed onto the lyophilized powder, because peptides are shear-sensitive
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Simultaneously, ROS disrupts insulin signaling in peripheral tissues by promoting IRS-1 serine phosphorylation and degrading phosphatidylinositol-3-kinase (PI3K)/Akt activation, leading to insulin resistance (Papaetis et al., 2025)