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Ongoing phase 3 trials are in progress, and CagriSema is currently under FDA review, with a decision expected in late 2026

Patients with personal or family history of medullary thyroid cancer or multiple endocrine neoplasia syndrome type 2 should not use semaglutide

In the ESSENCE trial involving participants with biopsy-confirmed MASH and stage 2 or 3 fibrosis, over half of whom had T2DM, interim analysis at 72 weeks showed 63% of those treated with semaglutide 2.4 mg weekly achieved resolution of steatohepatitis without worsening of fibrosis, compared with 34% in the placebo group

however, drug costs are generally created at the UN or ML level