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giving a prevalence of pathogenic MC4R mutations of 1.4% ( n = 32/2,291) in adults with obesity in the SURMOUNT-1 study (Extended Data Table 1)

Gastrointestinal Issues: Nausea, vomiting, diarrhea, constipation, and stomach discomfort are frequently reported

This helps regulate appetite, improve insulin sensitivity, and reduce blood sugar levels

The most effective protective measures: Enough protein

Endotoxins are fragments of bacterial cell walls (lipopolysaccharides) that persist even after bacteria are killed