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Moreover, KO mice for liver IGF-1 gene developed muscle insulin resistance (it is important to mention that skeletal muscle myocytes express high number of IGF-1R), showing an increase in insulin concentrations and a substantial decrease in the insulin-induced autophosphorylation of the insulin receptor and IRS in skeletal muscle (being normal in liver and white adipose tissue)

Balthasar N, Dalgaard LT, Lee CE, Yu J, Funahashi H, Williams T, et al

Role of L-carnitine in metabolism, nutrition and therapy